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Introduction to Bioinformatics · LearnSpace
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Introduction to Bioinformatics

Курс от Birla Institute of Technology & Science, Pilani
Начальный≈ 35.3 чАнглийский
О курсеНавыкиПрограммаПреподаватели

О курсе

Unlock the future of biological data analysis with our "Introduction to Bioinformatics" course. This comprehensive course combines bioinformatics, molecular biology, and computational techniques, equipping you with the skills to analyze complex biological and clinical data. Beginning with fundamental concepts, the course explores advanced topics like RNA sequencing analysis, single-cell genomics, gene-gene association studies, and medical text mining. You'll gain hands-on experience by working with real-world datasets from renowned databases such as NCBI, TCGA, and PubMed, using cutting-edge tools and frameworks. Our course balances theoretical understanding with practical implementation, priming you for roles in biotechnology, pharmaceuticals, and healthcare. Targeted at biology and computer science students, early-career scientists transitioning into bioinformatics, and healthcare professionals keen on computational methods for improved patient care, the course also suits data analysts and researchers seeking to enhance their bioinformatics skills. Ideal job roles post-completion include bioinformatics analyst, computational biologist, research scientist, and healthcare data specialist. Whether you're advancing your bioinformatics career or enhancing research capabilities, this course offers essential knowledge and skills to succeed in today's data-driven world. Enrol now to transform your passion for biological data into a rewarding career.

Навыки, которые вы освоите

BioinformaticsApplied Machine LearningData AnalysisUnsupervised LearningLarge Language ModelingData ManagementChemical and Biomedical EngineeringPrecision MedicineDimensionality ReductionData PreprocessingLLM ApplicationScientific VisualizationAlgorithmsComputational ThinkingData MiningCorrelation AnalysisMarkov ModelCell BiologyNetwork ModelClinical Data Management

Программа курса

10 модулей · 241 учебных материалов

01Introduction to Bioinformatics30 материалов

Let's Get Started

About BioinformaticsВидеоCourse OverviewЧтениеMeet Your Instructor - Prof. Saby JohnВидеоMeet Your Instructor - Prof. Seetha ParameswaranВидео

Учитесь у экспертов

BITS Pilani Instructors Group

Преподаватель курса

Introduction to Bioinformatics
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Обучение откроется на Coursera
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Обучение на Coursera

≈ 35.3 ч

10 модулей

Язык: Английский

Часть программы вашего университета
Meet Your Instructor - Dr. Reddy Rani VВидео
Course Structure & Critical InformationЧтение

Introduction to Bioinformatics

Definition of BioinformaticsВидеоApplication of BioinformaticsВидеоKey Functions of BioinformaticsВидеоDive Deeper: Introduction to BioinformaticsЧтениеCheck Your Understanding: BioinformaticsЗадание

Subfields of Bioinformatics

ClassificationВидеоAssemblyВидеоResequencingВидеоQuantificationВидеоThe Diverse Landscape of Bioinformatics: Understanding Key SubfieldsЧтениеNavigating the Bioinformatics Landscape: Choosing the Right Approach for Biological QuestionsDIALOGUECheck Your Understanding: Subfields of BioinformaticsЗадание

Bioinformatics Data

DataВидеоBioinformatics DataВидеоDive Deeper: Handling Biological DataЧтениеCheck Your Understanding: Bioinformatics DataЗадание

Python For Bioinformatics

Python and BioPythonВидеоDemo: Pandas and Matplotlib ВидеоPython Notebooks used for DemosЧтениеDive Deeper: Introduction to Python for BioinformaticsЧтениеCheck Your Understanding: Python For BioinformaticsЗадание

Discussion and Assignment

Advancements in Bioinformatics Data Analysis for Cancer ResearchDIALOGUELet's Practice: Introduction to BioinformaticsЗаданиеTest Yourself: Introduction to BioinformaticsЗадание
02Biology for Bioinformatics27 материалов

Life, Systematics and Evolution

Living (Cellular) vs Non-Living (Virus, Viroid, Prion)ВидеоDive Deeper: Living vs Non-Living EntitiesЧтениеVirusesВидеоDive Deeper: Introduction to Viruses ЧтениеClassification of Life ВидеоDive Deeper: Classification of Life ЧтениеEvolutionВидеоDive Deeper: EvolutionЧтениеCheck Your Understanding: Life, Systematics and EvolutionЗадание

The Living Cell

Structure of Bacterial, Plant, Animal CellsВидеоDive Deeper: Structure of Bacterial, Plant, Animal Cells ЧтениеTypes of Cells in HumanВидеоDive Deeper: Types of Cells in Human ЧтениеCancerВидеоDive Deeper: CancerЧтение

Chromosomes, DNA, RNA and Proteins

Bacterial and Eukaryotic ChromosomesВидеоDive Deeper: Bacterial and Eukaryotic Chromosomes ЧтениеDNA, RNA - Structure and FunctionВидеоDive Deeper: DNA, RNA - Structure and Function ЧтениеProtein Structure and FunctionВидеоDive Deeper: Protein Structure and Function Чтение

Discussion and Assignment

Unveiling the Secrets of SARS-CoV-2: A Deep Dive into Life, Evolution, and Cellular InteractionsDIALOGUELet's Practice: Biology for BioinformaticsЗаданиеTest Yourself: Biology for BioinformaticsЗадание
03Molecular Biology for Bioinformatics27 материалов

DNA Replication, Mutations and Sequencing

DNA Replication ВидеоDive Deeper: DNA ReplicationЧтениеDNA MutationsВидеоDive Deeper: DNA Mutations ЧтениеNucleic Acid SequencingВидеоDive Deeper: Nucleic Acid Sequencing ЧтениеCheck Your Understanding: DNA Replication, Mutations and SequencingЗадание

Gene Structure, Regulation and Expression

Gene Structure & Regulation in ProkaryotesВидеоDive Deeper: Gene Structure & Regulation in Prokaryotes ЧтениеGene Structure & Regulation in EukaryotesВидеоDive Deeper: Gene Structure and Regulation in Eukaryotes ЧтениеGenes and GenomicsВидеоDive Deeper: Genes and Genomics Чтение

The Central Dogma

The Central Dogma - OverviewВидеоDive Deeper: The Central Dogma - OverviewЧтениеTranscription (DNA to RNA)ВидеоDive Deeper: Transcription (DNA to RNA)ЧтениеTranslation (RNA to Protein)ВидеоDive Deeper: Translation (RNA to Protein)Чтение

Discussion and Assignment

Understanding Cystic Fibrosis (CF) Through Molecular BiologyDIALOGUELet's Practice: Molecular Biology for BioinformaticsЗаданиеTest Yourself: Molecular Biology for BioinformaticsЗадание
04Patient Subtyping Using RNA-Seq Data23 материалов

Data Extraction & Preprocessing

Why Patient SubtypingВидеоRetrieving RNA-Seq Data - NCBI GEO Database ВидеоNormalisation of RNA-Seq DataВидеоEssential Reading: Data Extraction and Preprocessing ЧтениеCheck Your Understanding: Data Extraction & PreprocessingЗадание

Clustering Algorithms

Patient Subtyping MethodsВидеоHierarchical Clustering Part AВидеоHierarchical Clustering Part BВидеоLouvain AlgorithmВидеоEssential Reading: Clustering Algorithms ЧтениеCheck Your Understanding: Clustering AlgorithmsЗадание

Validating the Subtypes

Kaplan-Meier CurvesВидеоConclusion and Findings ВидеоEssential Reading: Validating the Subtypes ЧтениеCheck Your Understanding: Validating the SubtypesЗаданиеDemo of Downloading Data from NCBIВидеоDemo of Hierarchical ClusteringВидео

Discussion and Assignment

Clustering Methods for Precision MedicineDIALOGUELet's Practice: Patient Subtyping using RNA-Seq DataЗаданиеTest Yourself: Patient Subtyping using RNA-Seq DataЗадание
05Cell Classification Using Single Cell RNA-Seq Data22 материалов

Introduction to Single-Cell RNA Sequencing

RNA-Seq vs scRNA-Seq StudyВидеоClassification of CellsВидеоCheck your understanding: Introduction to Single-Cell RNA SequencingЗаданиеDive Deeper: Introduction to Single-Cell RNA SequencingЧтение

Dimensionality Reduction and Visualisation

Feature SelectionВидеоPrincipal Component Analysis (PCA)ВидеоVisualising High Dimension DataВидеоCheck your understanding: Dimensionality Reduction and VisualisationЗаданиеDive Deeper: Dimensionality Reduction and VisualisationЧтение

Classifying Cells of Lung Cancer Data

Decision Tree FundamentalsВидеоEvaluating Classification ResultsВидеоConnecting Cell Classification to Network Biology: Preparing for Gene-Gene InteractionsDIALOGUECheck your understanding: Classifying Cells of Lung Cancer DataЗаданиеDive Deeper: Classifying Cells of Lung Cancer DataЧтениеDemo: Dimensionality Reduction using Principle Component AnalysisВидео

Discussion and Assignment

Exploring Cellular Diversity and ClassificationDIALOGUELet's Practice: Cell Classification Using Single Cell RNA-Seq DataЗаданиеTest Yourself: Cell Classification Using Single Cell RNA-Seq DataЗадание
06Gene-Gene Association Analysis of a Phenotype23 материалов

Data for Gene-Gene Association Studies

TCGA Database OverviewВидеоUnderstanding Gene-Gene AssociationsВидеоData DownloadingВидеоData Normalisation TechniquesВидеоCheck your understanding: Data for Gene-Gene Association StudiesЗаданиеDive Deeper: Data for Gene-Gene Association StudiesЧтение

Network Construction

Network Construction – Part AВидеоNetwork Construction – Part BВидеоCheck your understanding: Network ConstructionЗаданиеDive Deeper: Network ConstructionЧтение

Network Science

Visualisation using CytoscapeВидеоUnderstanding Graph Theory - Part AВидеоUnderstanding Graph Theory - Part BВидеоCheck your understanding: Network ScienceЗаданиеDive Deeper: Network ScienceЧтениеDemo: TCGA DownloadВидео

Discussion and Assignment

Integrating Multi-Omics Data for Comprehensive Breast Cancer AnalysisDIALOGUELet's Practice: Gene-Gene Association Analysis of a PhenotypeЗаданиеTest Yourself: Gene-Gene Association Analysis of a PhenotypeЗадание
07Gene Ontology & Pathway Enrichment Analysis24 материалов

Foundations of Enrichment Analysis

Introduction to Gene Enrichment and Pathway AnalysisВидеоGene Lists and Background SetsВидеоIntroduction to Gene OntologyВидеоCheck Your Understanding: Foundations of Enrichment AnalysisЗаданиеDive Deeper: Gene Enrichment AnalysisЧтение

Gene Ontology and Pathway Enrichment

Statistical Methods in Enrichment AnalysisВидеоFisher’s Exact Test ВидеоChi-Square TestВидеоMultiple Comparisons TestВидеоFrom Statistics to Biological Meaning: Interpreting Enrichment Analysis ResultsDIALOGUECheck Your Understanding: Gene Ontology and Pathway EnrichmentЗаданиеDive Deeper: Statistical methods in Gene Enrichment StudiesЧтение

Interpretation and Visualisation

DAVID - Gene Enrichment Tool ВидеоPathway Interaction NetworkВидеоCheck Your Understanding: Interpretation and VisualisationЗаданиеDive Deeper: Interpretation and VisualisationЧтениеDemo: Statistical Methods for Gene Significance AnalysisВидеоDemo: Using STRING for Analyzing PPIsВидео

Discussion and Assignment

Advancing Disease Research with Pathway Interaction NetworksDIALOGUELet's Practice: Gene Ontology & Pathway Enrichment AnalysisЗаданиеTest Yourself: Gene Ontology & Pathway Enrichment AnalysisЗадание
08NLP Foundations19 материалов

Foundations of NLP

Introduction to NLP FundamentalsВидеоNLP Libraries (NLTK, spaCy)ВидеоText Preprocessing TechniquesВидеоCheck Your Understanding: Foundations of NLPЗаданиеEssential Reading: Foundations of NLPЧтение

Text Analysis

Named Entity RecognitionВидеоPattern MatchingВидеоRule Based SystemВидеоContextual AnalysisВидеоCheck Your Understanding: Text AnalysisЗаданиеDive Deeper: Text AnalysisЧтениеDemo: Text Processing using NLTKВидеоDemo: Medical NER using NLTK ВидеоDemo: Medical Text AnalysisВидеоFiles Used for DemosЧтениеCheck Your Understanding: Using NLTKЗадание

Discussion and Assignment

Ethical and Practical Challenges in Handling Medical Data for NLPDIALOGUELet's Practice: NLP FoundationsЗаданиеTest Yourself: NLP FoundationsЗадание
09Knowledge Discovery24 материалов

Medical Text Mining Foundations

Introduction to Medical NLPВидеоPubMed Data StructureВидеоMedical OntologiesВидеоCheck Your Understanding: Medical Text Mining FoundationsЗаданиеDive Deeper: Medical Text Mining FoundationsЧтение

Introduction to Transformers

TransformersВидеоBERT and BioBERT ModelsВидеоCheck Your Understanding: Introduction to TransformersЗаданиеDive Deeper: Introduction to TransformersЧтение

Relationship Mining

Relationship ExtractionВидеоDisease-Symptom RelationshipsВидеоDrug-Disease RelationshipsВидеоComorbidity DetectionВидеоCheck Your Understanding: Relationship MiningЗаданиеDive Deeper: Relationship MiningЧтение

Discussion and Assignment

From Text to Genome: Integrating Knowledge Extraction Across Bioinformatics DomainsDIALOGUELet's Practice: Knowledge DiscoveryЗаданиеTest Yourself: Knowledge DiscoveryЗадание
10DNA Data Analysis22 материалов

DNA Data

DNA Data AnalysisВидеоUnderstanding Raw DNA DataВидеоData Import and CleaningВидеоCheck Your Understanding: DNA DataЗаданиеDive Deeper: DNA DataЧтение

DNA Matching

Genetic Distance MetricsВидеоDNA Matching AlgorithmsВидео Check Your Understanding: DNA MatchingЗаданиеDive Deeper: DNA MatchingЧтение

Relationship Prediction System and Visualisation

Building a Relationship Prediction SystemВидеоChromosome VisualisationВидеоCheck Your Understanding: Relationship Prediction System and VisualisationЗаданиеDive Deeper: Relationship Prediction System and VisualisationЧтениеDemo: Generating Synthetic DNA Data and Calculating Distance MetricsВидеоDemo: DNA Matching Algorithms and Statistical AnalysisВидео

Discussion and Assignment

Ethical Considerations in DNA Relationship PredictionDIALOGUELet's Practice: DNA Data AnalysisЗаданиеTest Yourself: DNA Data AnalysisЗадание

Course Wrap-up

Course SummaryЧтение
Check Your Understanding: The Living CellЗадание
Connecting Biology to Bioinformatics: From Biomolecules to Computational AnalysisDIALOGUE
Check Your Understanding: Chromosomes, DNA, RNA and ProteinsЗадание
Check Your Understanding: Gene Structure, Regulation and ExpressionЗадание
Genetic Code Видео
Dive Deeper: Genetic Code Чтение
Molecular Biology Integration: Connecting the Flow of Genetic InformationDIALOGUE
Check Your Understanding: The Central DogmaЗадание
Demo of Louvain ClusteringВидео
Essential Reading: Files Used for DemosЧтение
Check Your Understanding: Clustering TechniquesЗадание
Demo: Implementing Decision Tree for Cell Type ClassificationВидео
Demo: Implementing a Confusion MatrixВидео
Python Notebooks Used for DemosЧтение
Check your understanding: Dimensionality Reduction using Principle Component AnalysisЗадание
Demo: Implementing Network ConstructionВидео
Demo: Cytoscape ExplorationВидео
Files Used for DemosЧтение
Check your understanding: Using CytoscapeЗадание
Files Used for DemosЧтение
Dive Deeper: Advanced Statistical Methods for Gene Category AnalysisЧтение
Check Your Understanding: Using STRINGЗадание
Demo: Drug-Disease Relationship Extraction Using NLTKВидео
Demo: Disease Symptom Relationship Using NLTK Видео
Demo: Comorbidity Detection Using NLTKВидео
Demo: Relationship Extraction Using BioBERTВидео
Files Used for DemosЧтение
Check Your Understanding: Relationship Mining using NLTK and BioBERTЗадание
Demo: Relationship Prediction and Model EvaluationВидео
Demo: Chromosome IdeogramВидео
Files Used for DemosЧтение