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Clinical Pharmacokinetics: Dosing and Monitoring · LearnSpace
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Clinical Pharmacokinetics: Dosing and Monitoring

Курс от Taipei Medical University
Средний≈ 18.9 чАнглийский
О курсеНавыкиПрограммаПреподаватели

О курсе

This course covers the core principles of clinical pharmacokinetics, including drug absorption, distribution, metabolism, excretion, and binding. In modern clinical practice, determining the correct dose is never a guessing game—it is a precise science where patient safety is continually on the line. Moving beyond abstract equations, this course explores how these core principles dictate real-time patient care on the hospital floor. We demystify complex mathematical concepts through innovative, visual frameworks like the foundational "Fish Tank" model, making first-order elimination and distribution intuitive to grasp. As the course unfolds, learners will investigate the critical challenges of assessing renal and hepatic clearance and uncover how shifting biological variables impact serum drug concentrations. Grounded in rigorous clinical case studies and enriched by the instructor's active academic research, the curriculum focuses heavily on managing critical antibiotics such as vancomycin and aminoglycosides. Designed for pharmacy students and healthcare professionals, this course bridges the gap between scientific theory and front-line application. You will walk away with the definitive problem-solving skills needed to confidently evaluate, monitor, and tailor life-saving medication regimens for individual patients.

Навыки, которые вы освоите

Clinical MonitoringPharmacologyPharmacotherapyPharmaceuticalsMedication DispensationContinuous MonitoringDrug InteractionPharmaceutical TerminologyNephrologyBiochemistryMedication Therapy ManagementAnalytical TestingMathematical ModelingPharmacyBiotechnologyDrug DevelopmentPatient SafetyPhysiologyClinical ResearchMedical Prescription

Программа курса

7 модулей · 62 учебных материалов

01The Fish Tank – A Simplified Model of First-Order Elimination11 материалов

Weekly Overview & Instructor Slides

Module 1: The Fish Tank – A Simplified Model of First-Order Elimination!Чтение

The Fish Tank Model - Introduction and Definition

1.1 What is the "Fish Tank Model"?Видео1.2 Important parameters in the Fish Tank 1: Volume, Clearance, and k Видео1.3 The relationship between Volume, Clearance, and k

Учитесь у экспертов

Hsiang-Yin Shawn Chen

Преподаватель курса

Clinical Pharmacokinetics: Dosing and Monitoring
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Обучение на Coursera

≈ 18.9 ч

7 модулей

Язык: Английский

Часть программы вашего университета
Видео
1.4 Important parameters in the Fish Tank 2: Half-life, Serum Concentration, and AUCВидео
1.5 Important parameters in the Fish Tank 3 : Mean Residence Time and Protein BindingВидео
1.6 The factors affect Clearance : SummaryВидео

Rewind & Reflect: Module1 Practice Quiz

Fish Tank Theroy ЗаданиеMentoring Dr. Davis: Applied Clinical PharmacokineticsDIALOGUEUsing the Fish Tank Model as a teaching tool for pharmacokineticsЧтение

Summative Evaluation

The Fish Tank – A Simplified Model of First-Order EliminationЗадание
02Dosing Basics – How to Determine the Right Amount of Drug for a Patient9 материалов

Weekly Overview & Instructor Slides

Module 2: Dosing Basics – How to Determine the Right Amount of Drug for a Patient!Чтение

Dosing Basics – How to Determine the Right Amount of Drug for a Patient

2.1 How to determine an effective dose : the importance of a loading dose?Видео2.2 Which factor(s) impacts the loading dose? Видео2.3 The multiple dosing regimen : how to identify the most practical dosing regimen? Видео2.4 The concept of an accumulation factorВидео2.5 Summary: The keys to optimal drug dosingВидео

Rewind & Reflect: Module2 Practice Quiz

Pharmacokinetic-Based Design and Modification of Dosage RegimensЧтениеPredicting Changes in Drug ConcentrationЗадание

Summative Evaluation

Dosing Basics – How to Determine the Right Amount of Drug for a PatientЗадание
03The Ups and Downs of Predicting Changes in Drug Concentration10 материалов

Weekly Overview & Instructor Slides

Module 3: The Ups and Downs of Predicting Changes in Drug ConcentrationЧтение

Predicting changes in drug concentration

3.1 How to predict changes in serum concentration?Видео3.2 How to change dose or dosing interval in response to a change in volume, clearance, or k ?Видео3.3 How do clearance and volume impact the serum concentration? Видео3.4 What happens when volume increases?Видео3.5 Protein binding: the impact of unbound drugВидео3.6 What has changed before and after steady-state : SummaryВидео

Rewind & Reflect: Module3 Practice Quiz

Review of Predicting Changes in Drug ConcentrationЗаданиеApplied Clinical PharmacokineticsЗадание

Summative Evaluation

The Ups and Downs of Predicting Changes in Drug ConcentrationЗадание
04The Challenges of Assessing Renal and Hepatic Clearance12 материалов

Weekly Overview & Instructor Slides

Week 4:The Challenges of Assessing Renal and Hepatic Clearance.Чтение

Renal and hepatic dose adjustment

4.1 How to assess the need to change drug dosing ? Видео4.2 Sources of error of the Cockcroft-Gault equation: How to adjust a CLcr or GFR ?Видео4.3 When to adjust the dose for patients having renal failure?Видео4.4 Example: how to avoid overestimating and underestimating a patient's renal functionВидео4.5 Hepatic Blood Flow & First-Pass EffectВидео4.6 Factor(s) affects Low E and High E drugsВидео4.7 Hepatic Metabolism Review : How will Css change if fu changes?Видео4.8 Michaelis- Menten Non-Linear metabolism & summaryВидео

Rewind & Reflect: Module4 Practice Quiz

Review of Assessing Renal and Hepatic ClearanceЗаданиеClinical Debrief: Pharmacokinetics and Dose AdjustmentsDIALOGUE

Summative Evaluation

The Challenges of Assessing Renal and Hepatic ClearanceЗадание
05What Pharmacists Need to Know about Dosing Aminoglycosides and Vancomycin11 материалов

Weekly Overview & Instructor Slides

What Pharmacists Need to Know about Dosing Aminoglycosides and Vancomycin Чтение

How to optimize efficacy and minimize toxicity on dosing Vancomycin and Aminoglycoside?

5.1 The ideas pharmacists need to know about dosing Aminoglycosides and VancomycinВидео5.2 PK differences and Traditional Vancomycin DosingВидео5.3 How to determine a Vancomycin dosing regimen based on AUIC? Видео5.4 Advantages of Vancomycin continuous infusion and Traditional AMG dosing Видео5.5 Intermittent infusion dosing & AMG serum level analysisВидео5.6 Once-daily (Extended-Interval) Aminoglycoside Dosing & SummaryВидео

Rewind & Reflect: Module5 Practice Quiz

Dosing aminoglycosides and vancomycinОбсуждениеReview of Dosing Vancomycin and AminoglycosideЗаданиеClinical Mentorship: Guiding a Resident on Antibiotic DosingDIALOGUE

Summative Evaluation

What Pharmacists Need to Know about Dosing Aminoglycosides and VancomycinЗадание
06Clinical Application - Vancomycin and Gentamycin Case Practice7 материалов

Weekly Overview & Instructor Slides

Clinical Application — Vancomycin and Gentamicin Case PracticeЧтение

Clinical recommendations on the dose adjustment on Vancomycin and Aminoglycoside

6.1 Clinical recommendations on the therapeutic monitoring of VancomycinВидео6.2 Clinical indications of AMG & PK/PD optimization of Antibiotic therapyВидео6.3 Summary : Case practiceВидео

Rewind & Reflect: Module6 Practice Quiz

A Consensus Review of VancomycinЧтениеVancomycin and Gentamycin CaseЗадание

Summative Evaluation

Clinical application - vancomycin and gentamycin case practiceЗадание
07Final Review2 материалов
Final ReviewЗаданиеCourse feedback and reflectionОбсуждение