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Introduction to Small Molecule Drug Discovery & Development · LearnSpace
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Introduction to Small Molecule Drug Discovery & Development

Курс от University of Cape Town
Начальный≈ 18 чАнглийский
О курсеНавыкиПрограммаПреподаватели

О курсе

What does it take to advance a new drug from the laboratory bench to the patient’s bedside? Historically, drugs were discovered serendipitously and were usually isolated from natural sources. Today, drug discovery efforts take many years and cost hundreds of millions of dollars. They also require the input of dozens of specialists from a multitude of backgrounds to ensure that therapeutic molecules are efficacious and safe. This four-week course takes a high-level tour of what it takes to research and develop a new drug. We will meet different scientists and professionals across the drug discovery value chain as we explore the different stages of discovery and development, including the different tools and technologies that are influencing how we think about new medicines today. Starting off with the needs of the patient and the early phases of drug discovery, we will cover drug metabolism, pharmacokinetics and drug safety all the way to clinical development and beyond. This course is relevant for scientists who are new to drug discovery research or already have some experience, health professionals, or anyone who is interested in knowing what had to happen to ensure that their medicine is effective and safe.

Навыки, которые вы освоите

Drug DevelopmentInformed ConsentClinical TrialsPre-Clinical DevelopmentInfectious DiseasesChemistryMicrobiologyPatient-centered CarePharmaceuticalsClinical ResearchMedical Science and ResearchClinical Research EthicsPharmacologyGood Clinical Practices (GCP)Clinical Data Management

Программа курса

4 модулей · 77 учебных материалов

01The starting point for drug discovery: The needs of the patient 23 материалов

Welcome to the course

Course introductionВидеоHow the course worksЧтениеAbout the H3D Foundation, H3D Centre and Global Health at Merck KGaA, Darmstadt, Germany ЧтениеMeet the course teamЧтение

Introduction to the week

Учитесь у экспертов

Dr Susan Winks

Преподаватель курса

Introduction to Small Molecule Drug Discovery & Development
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Обучение на Coursera

≈ 18 ч

4 модулей

Язык: Английский

Субтитры: Дари, Пушту

Часть программы вашего университета
Introduction to week 1Видео
Concepts in week 1Чтение

Knowing the patient in the context of drug discovery

Case study 1: Malaria ВидеоIdentify characteristics of an unmet medical needОбсуждение

History and overview of drug discovery

History and overview of drug discoveryВидеоReference infographic: Drug discovery and development value chainЧтение

Drug discovery unpacked

Different approaches in drug discoveryВидеоThe four levels of validation in infectious disease drug discovery programmesЧтениеIdentifying a good drug candidate ВидеоIdentify disciplines involved in the various phases of drug discoveryОбсуждениеPanel discussion: How do academia and industry select and prioritise projects in the global health space?ВидеоCase study: MMV390048 – from a hit to the clinicЧтение

Consolidating the week

Practice quiz for week 1ЗаданиеGraded quiz for week 1ЗаданиеAdditional readings for week 1ЧтениеConclusion for week 1Видео

Optional: Careers in drug discovery research

A day in the life of a drug discovery researcher (PODCAST)ЧтениеA day in the life of a drug discovery researcher (VIDEO)ВидеоAre you considering a career as a drug discovery researcher?Обсуждение
02The early phases of drug discovery17 материалов

Introduction to the week

Introduction to week 2ВидеоConcepts in week 2ЧтениеCase study 2: Tuberculosis (TB)ВидеоDisease area and target product profile considerations Обсуждение

Unpacking disease biology

Disease biology and understanding mechanism of actionВидеоDruggable targets and target vulnerability in various physiological environments ВидеоDifferentiating between host and pathogen biologyВидеоIntroduction to medicinal chemistryЧтение

Medicinal chemistry and different approaches to drug discovery

Medicinal chemistry optimisationВидеоInterview with chemists in the lab as they optimise different physicochemical and biological propertiesВидеоIntroduction to screening cascadesВидеоPanel discussion: Industry versus academic approaches to early-stage drug discoveryВидеоContinuing the MMV390048 case studyЧтение

Consolidating the week

Practice quiz for week 2ЗаданиеGraded quiz for week 2ЗаданиеAdditional resources for week 2ЧтениеConcluding week 2Видео
03Drug metabolism, pharmacokinetics and drug safety 17 материалов

Introduction to the week

Introduction to week 3ВидеоConcepts in week 3ЧтениеIntroduction to in vitro absorption, distribution, metabolism and excretion (ADME)ВидеоIntroduction to drug metabolism and pharmacokinetics (DMPK)ВидеоSupplementary reading: ADME and DMPKЧтение

Efficacy in an animal model and animal welfare

In vivo efficacy (NSG mouse model)ВидеоPanel discussion: The role of animal testing in drug discoveryВидео

Dosage, toxicology and drug safety

Introduction to pharmacokinetic/pharmacodynamic (PK/PD) modelling and human dose predictionsВидеоPreclinical development: Selecting a compound for clinical trialsВидеоPreclinical pharmacology: Understanding toxicologyВидео

Process chemistry and API manufacturing

Panel discussion: Process chemistry and API manufacturingВидео

Consolidating the week

Practice quiz for week 3ЗаданиеGraded quiz for week 3ЗаданиеAdditional readings for week 3ЧтениеConcluding week 3Видео

Honors: Selecting an antimalarial drug candidate for development

Information about the Honors peer-reviewed assessmentЧтениеSelecting an antimalarial drug candidate for developmentВзаимная проверка
04Development phase20 материалов

Introduction to the week

Introduction to week 4ВидеоConcepts in week 4Чтение

Clinical trials

Introduction to clinical trialsВидеоRoles in clinical trialsЧтениеConcluding the MMV390048 case studyЧтение

Regulations

Panel discussion: Submission and approval by authorities to conduct clinical trials in humansВидеоPanel discussion: Informed consent process at the clinical research site ВидеоResearching regulationsЧтение

Clinical trial phase considerations

Optional - Panel discussion: Site dynamics during the conduct of a clinical trialВидеоPanel discussion: Study management budgets, contracts and vendorsВидеоPanel discussion: Data management and quality oversight during clinical trialsВидеоResearching clinical trial phase considerations Чтение

Commercial considerations and new technologies in drug discovery and development

Commercial considerations in global healthВидеоPanel discussion: New technologies changing the landscape of drug discovery and developmentВидеоAI in drug discovery Чтение

Consolidating the week

Practice quiz for week 4ЗаданиеGraded quiz for week 4ЗаданиеAdditional resources for week 4ЧтениеConcluding week 4Видео

End of course

More information Чтение