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Evidence-based Toxicology

Курс от Johns Hopkins University
Начальный≈ 19.5 чАнглийский
О курсеНавыкиПрограммаПреподаватели

О курсе

Welcome to the Evidence-based Toxicology (EBT) course. In medicine and healthcare, evidence-based medicine has revolutionized the way that information is evaluated transparently and objectively. Over the past ten years, a movement in North America and Europe has attempted to translate this revolution to the field of toxicology. The Center for Alternatives to Animal Testing (CAAT) within the department of Environmental Health and Engineering at the Johns Hopkins Bloomberg School of Public Health hosts the first chair for EBT and the secretariat for the EBT Collaboration on both sides of the Atlantic. Based on the Cochrane Collaboration in Evidence-based Medicine, the EBT Collaboration was established at the CAAT to foster the development of a process for quality assurance of new toxicity tests for the assessment of safety in humans and the environment. Regulatory safety sciences have undergone remarkably little change in the past fifty years. At the same time, our knowledge in the life sciences is doubling about every seven years. Systematic review and related evidence-based approaches are beginning to be adapted by regulatory agencies like the Environment Protection Agency (EPA), the European Food Safety Authority (EFSA), and the US National Toxicology Program. They provide transparent, objective, and consistent tools to identify, select, appraise, and extract evidence across studies. This course will showcase these emerging efforts and address opportunities and challenges to the expanded use of these tools within toxicology.

Навыки, которые вы освоите

Verification And ValidationResearch MethodologiesScientific MethodsRisk AnalysisQuantitative ResearchEnvironmental ScienceSafety AssuranceLaboratory TestingEnvironmental RegulationsGeneral Science and ResearchResearch DesignHazard AnalysisData SynthesisResearchProcess ValidationBioinformaticsScience and ResearchBiostatisticsEpidemiology

Программа курса

7 модулей · 83 учебных материалов

01Introduction & Shortcomings of Current Approaches14 материалов

Introduction

WelcomeВидеоIntroduction to the CourseВидеоLetter to LearnersЧтениеCourse Learning ObjectivesЧтение

Shortcomings of current approaches in toxicology

Учитесь у экспертов

Thomas Hartung

Professor

Lena Smirnova

Research Associate

Evidence-based Toxicology
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≈ 19.5 ч

7 модулей

Язык: Английский

Субтитры: Арабский, Французский, Украинский, Китайский (Китай), Греческий, Итальянский, Бразильский португальский, Нидерландский, Корейский, Немецкий, Пушту, Русский, Тайский, Индонезийский, Шведский, Турецкий, Испанский, Дари, Хинди, Японский, Казахский, Польский

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IntroductionВидео
Shortcoming No. 1: Narrative ReviewsВидео
Shortcoming No. 2: Bias in ReviewsВидео
Shortcoming No. 3: Evidence WritingВидео
Shortcoming No. 4: External ValidityВидео
Shortcoming No. 5: Assessing New MethodsВидео
Shortcoming No. 6: Inadequate ReportingВидео
Supporting readingЧтение

Check your knowledge

Rank the shortcomingsОбсуждениеPractice Quiz 1Задание
02History and Causation15 материалов

Welcome

Welcome to Module 2Видео

Start of Evidence-Based Toxicology

Personal First Exposures to Evidence-Based MedicineВидеоThe Start of EBTВидеоThe First Conference 2007 to the Start of the EBT Collaboration 2011ВидеоThe Evidence-Based Toxicology Collaboration (EBTC)ВидеоSupporting readingЧтение

Causation and Evidence-Based Toxicology

Introduction Causation vs. CorrelationВидеоThe Hill Principles of Epidemiology and their Relation to ToxicologyВидеоThe Problem of Causation in ToxicologyВидеоBiomarker Concept in Mechanistic ToxicologyВидеоMechanistic ValidationВидеоThe Future of Causation in Complex SystemsВидео

Review

Importance of EBTОбсуждениеPractice Quiz 2Задание
03Systematic Review and Meta-Analysis13 материалов

Welcome

Welcome to Module 3Видео

Systematic Reviews – principles and examples

Systematic Reviews: Definition and PrinciplesВидеоSystematic Reviews - Protocol DevelopmentВидеоSystematic Reviews - Protocol Development (Part 2)ВидеоSupporting readingЧтение

Introduction to Meta-analysis

HistoryВидеоMeta-analysis GuidelinesВидеоMeta-analysis Protocol, Part 1ВидеоMeta-analysis Protocol, Part 2ВидеоSupporting readingЧтение

Module 3 Review

Systematic Review and Meta-analysisОбсуждениеPractice Quiz 3Задание

Mid-course exam

Mid-course examЗадание
04Risk of Bias & Application to Test Methods Comparison12 материалов

Welcome

Welcome to Module 4Видео

Risk of Bias in Evidence-Based Toxicology

Introduction to Risk of Bias Concept in Critical Appraisal of StudiesВидеоExamples for Risk of Bias Tools 1: Cochrane CollborationВидеоExamples for Risk of Bias Tools 2: SYRCLE's RoB ToolВидеоExamples of Risk of Bias Tools 3: National Institute for Environmental Health Sciences (NIEHS) - OHATВидеоQuality Assessment in Evidence-Based ToxicologyВидеоSupporting readingЧтение

Evidence-Based Toxicology: Application to Test Methods Comparison

Evidence-Based Toxicology (EBT) and Evidence-Based Toxicology Collaboration (EBTC)ВидеоZebrafish Systematic ReviewВидеоSupporting readingЧтение

Module 4 Review

Risk of Bias is important to considerОбсуждениеPractice Quiz 4Задание
05Quality Assurance, Good Practices, and Validation14 материалов

Welcome

Welcome to Module 5Видео

Quality Assurance and Good Practices

The Concepts of Quality Assurance (QA) and Good Practice (GP)ВидеоGood PracticeВидеоQuality AssuranceВидеоImportance of GP and QA in EBTВидеоSupporting readingЧтение

Validation

The Evolution of Validation of Alternative MethodsВидеоThe Traditional Validation ProcessВидеоExample of a Validation Study: Skin IrritationВидеоDevelopments in the Validation AreaВидеоValidation and Tox-21c/EBTВидеоSupporting readingЧтение

Module 5 Review

Changes in the validation processОбсуждениеPractice Quiz 5Задание
06Biometrical Tools & Future Perspectives12 материалов

Welcome

Welcome to Module 6Видео

Biometrical Tools in Evidence-Based Toxicology

Why We Need Biometry/Statistics in Evidence-Based ToxicologyВидеоStatistics and Bioinformatics Applied in Evidence-Based Approaches IВидеоStatistics and Bioinformatics Applied in Evidence-Based Approaches IIВидеоRisk and Bias and Its Impact on Evidence-Based ApproachesВидео

Future Perspectives of Evidence-Based Toxicology

Evidence-Based Is a More Rigorous Scientific Approach to AnythingВидеоThe Reproducibility Crisis in ScienceВидеоWhere Is Evidence-Based Toxicology (EBT) and What Are The Next Steps?ВидеоSupporting readingЧтение

Module 6 Review

Reproducibility crisisОбсуждениеPractice quiz 6Задание

Final exam

Final examЗадание
07Summative Assessment - Systematic Review Assignment3 материалов

Assignment

Systematic Review Assignment InstructionsЧтениеSysRev DemoPLUGINSystematic Review Assignment ResultsЗадание
Supporting readingЧтение