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Genetic Epidemiology Foundations · LearnSpace
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Genetic Epidemiology Foundations

Курс от University of Colorado System
Средний≈ 16.9 чАнглийский
О курсеНавыкиПрограммаПреподаватели

О курсе

This course is presented by the University of Colorado Denver in collaboration with the Vanderbilt Genetics Institute at Vanderbilt University Medical Center and the International Genetic Epidemiology Society. It is designed to provide students with the background and knowledge foundations necessary to conduct statistical analysis of genetic association study data. This course includes multiple lectures and evaluations on each of the topics: the history of genetics research presented by Dr. Nancy Cox, foundational concepts in population genetics presented by Dr. Bruce Weir, population structure in genetic association studies presented by Dr. Todd Edwards, quality control in genetic studies presented by Dr. Goncalo Abecasis, analysis of population-based case-control association studies presented by Dr. Celia Greenwood, and analysis of family-based studies presented by Dr. Joan Bailey-Wilson. Examples of concepts and reference literature are also provided in this 6-module course.

Навыки, которые вы освоите

EpidemiologyStatistical AnalysisBiostatisticsData QualityRegression AnalysisData ValidationAnalysisMolecular BiologyStatistical MethodsProbability & StatisticsStatistical ModelingMedical Science and ResearchData Cleansing

Программа курса

6 модулей · 104 учебных материалов

01What is Genetic Epidemiology? Historical Perspective and Introduction17 материалов

Course Introduction

Acknowledgements and InstructorsЧтениеCourse IntroductionВидеоGlossaryЧтениеGet help and meet other learners. Join your Community!Чтение

Introduction to Genetic Epidemiology

Учитесь у экспертов

Todd Edwards

Ph.D.

Stephanie A. Santorico

Ph.D.

Genetic Epidemiology Foundations
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≈ 16.9 ч

6 модулей

Язык: Английский

Субтитры: Арабский, Французский, Украинский, Китайский (Китай), Греческий, Итальянский, Бразильский португальский, Нидерландский, Корейский, Немецкий, Русский, Тайский, Индонезийский, Шведский, Турецкий, Испанский, Хинди, Японский, Казахский, Польский

Часть программы вашего университета
Module 1 Introduction: What is Genetic Epidemiology?Видео
Origins of Genetic EpidemiologyВидео
Legacies of these Origins and Scientific RigorВидео

Liability and Threshold Models

Liability and Threshold Models: IntroductionВидеоTesting and an ExampleВидеоGenetic Regulation of Gene ExpressionВидео

Omics Imputation

IntroductionВидеоMethodsВидеоMethods Continued and ExtensionВидеоPleiotropyВидео

Summative Assessment

References and LinksЧтениеModule 1 Discussion PromptОбсуждениеModule 1 Summative AssessmentЗадание
02Introduction to Population Genetics: Models and Assumptions19 материалов

Hardy-Weinberg Equilibrium

Introduction to Population GeneticsВидеоHardy-Weinberg Equilibrium Definition and ImplicationsВидеоHWE Testing and P-ValuesВидеоHWE Testing Power, QQ Plots, and Multiple TestsВидеоHW Departures and Population StructureВидео

Genetic Drift

Genetic Drift IВидеоGenetic Drift IIВидео

Population Structure

Population Structure IВидеоPopulation Structure IIВидео

Inbreeding and Relatedness

Inbreeding and Relatedness IВидеоInbreeding and Relatedness IIВидеоInbreeding and Relatedness IIIВидео

Linkage Disquilibrium

Linkage Disquilibrium IВидеоLinkage Disquilibrium IIВидеоLinkage Disquilibrium IIIВидеоLinkage Disquilibrium IVВидео

Summative Assessment

Related ArticlesЧтениеModule 2 Discussion PromptОбсуждениеModule 2 Summative AssessmentЗадание
03Population Structure and Genetic Association Studies16 материалов

Factors that Influence Population Structure

Population StructureВидеоDefinition of Population Structure and Brief Overview of Human HistoryВидеоFactors the Influence Population Structure and Genetic DriftВидеоNatural SelectionВидеоExamples of Population Structure in Modern HumansВидеоPima ExampleВидео

Statistical Methods

Statistical Methods I: Structured Association and Genomic ControlВидеоStatistical Methods II: Principal Components AnalysisВидеоStatistical Methods III: LD Score RegressionВидеоStatistical Methods IV: Principal ComponentsВидеоStatistical Methods V: Mixed ModelsВидеоStatistical Methods VI: Admixture MappingВидео

Summative Assessment

Resources Part 1ЧтениеResources Part 2ЧтениеNew Discussion PromptОбсуждениеModule 3 Summative AssessmentЗадание
04 Basic Quality Control in Genetic Data: Data Structure14 материалов

Introduction

Basic Quality Control in Genetic DataВидеоMotivation and BackgroundВидео

Quality Control

Introduction to Quality ControlВидеоQQplots: Part 1ВидеоQQplots: Part 2ВидеоMendelian Inconsistency ChecksВидео

Population Structure

Population Structure: Part 1ВидеоPopulation Structure: Part 2Видео

Genotype Imputation

Genotype Imputation: IntroductionВидеоGenotype Imputation: The Details, Part 1ВидеоGenotype Imputation: The Details, Part 2Видео

Summative Assessment

Module 4 Discussion PromptОбсуждениеModule 4 Summative AssessmentЗаданиеOptional ReadingsЧтение
05Population-Based Association Studies17 материалов

Introduction

Population-Based Association StudiesВидео

Basic Measures

Basic Measures: Part 1Видео Basic Measures: Part 2Видео

Common Modeling Strategies

Common Modeling Strategies: Part 1ВидеоCommon Modeling Strategies: Part 2Видео

Multiple Testing

Introduction to Multiple Testing: Part 1ВидеоIntroduction to Multiple Testing: Part 2Видео

Reproducibility

Reproducibility: Part 1ВидеоReproducibility: Part 2Видео

Genotype Imputation

Introduction to Genotype Imputation: Part 1ВидеоIntroduction to Genotype Imputation: Part 2Видео

Meta-Analysis and Consortia

Introduction to Meta-Analysis and Consortia: Part 1ВидеоIntroduction to Meta-Analysis and Consortia: Part 2ВидеоIntroduction to Meta-Analysis and Consortia: Part 3Видео

Summative Assessments

ResourcesЧтениеModule 5 Discussion PromptОбсуждениеModule 5 Summative AssessmentЗадание
06Family-Based Designs21 материалов

Introduction

Family-Based DesignsВидео

Familial Aggregation

OverviewВидеоFamilial ClusteringВидеоTwin StudiesВидеоOther DesignsВидео

Segregation Analysis

Classical MethodsВидеоModern MethodsВидео

Linkage Analysis

Basics Part 1ВидеоBasics Part 2ВидеоRecombination and MappingВидеоParametric MethodsВидеоModel-Free MethodsВидео

Association Analysis

Overview Part 1ВидеоOverview Part 2ВидеоTypes of MethodsВидео

Rare Variants

OverviewВидеоLinkageВидеоAssociationВидео

Summative Assessments

Module 6 Discussion PromptОбсуждениеModule 6 Summative AssessmentЗаданиеReferences and SoftwareЧтение