Hacking COVID-19: Metabolic Pathway Analysis Yields SARS-CoV-2 Drug Targets

О курсе

Pathway Bioinformatics is a subfield of Bioinformatics that is concerned with computationally deriving functional insights from genomic data through analysis of molecular networks. This course will present principles and techniques from Pathway Bioinformatics, and will apply these methodologies to the search for drug targets for SARS-CoV-2. The course will begin by discussing motivations for Pathway Bioinformatics, and by presenting an overview of metabolism and of metabolic pathways. Next it will discuss machine representation of pathway data, and methods for pathway visualization. The course will describe how the metabolic pathways of an organism can be inferred from genome data, and how pathways can be used to interpret high-throughput data such as transcriptomics data. It will show how to predict the essential genes of an organism via reachability analysis, and then present a metabolic analysis of human metabolism when interacting with SARS-CoV-2 to predict SARS-CoV-2 drug targets.

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Учитесь у экспертов

Mikhail Rayko

Senior Researcher

Niema Moshiri

Associate Teaching Professor

Vikram Sirupurapu

Master’s Student

Peter Karp

Technical Director Artificial Intelligence Center

Lily Steiner

Преподаватель курса

Sabeel Mansuri

Software Engineer

Pavel Pevzner

Professor