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Case Studies in Personalized Medicine · LearnSpace
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Case Studies in Personalized Medicine

Курс от Vanderbilt University
Уровень не указан≈ 19.2 чАнглийский
О курсеНавыкиПрограммаПреподаватели

О курсе

Learn how advances in biomedicine hold the potential to revolutionize drug development, drug treatments, and disease prevention: where are we now, and what does the future hold? This course will present short primers in genetics and mechanisms underlying variability in drug responses. A series of case studies will be used to illustrate principles of how genetics are being brought to bear on refining diagnoses and on personalizing treatment in rare and common diseases. The ethical and operational issues around how to implement large scale genomic sequencing in clinical practice will be addressed. After completing this course, learners will understand 1. The ways in which genetic variants can contribute to human disease susceptibility 2. How to choose among drug therapies based on genetic factors 3. That the functional consequences of the vast majority of genetic variants discovered by modern sequencing are unknown. This course is targeted primarily at physicians 5+ years out of training. Other healthcare providers, medical/health sciences students, and members of the public may also be interested. Course launches January 15, 2016. * The information presented in “Case Studies in Personalized Medicine” is offered for educational and informational purposes only, and should not be construed as personal medical advice. If you have questions or concerns about a medical matter, please consult your doctor or other professional healthcare provider.

Навыки, которые вы освоите

BiostatisticsBioinformaticsPrecision MedicineDrug InteractionElectronic Medical RecordStatistical AnalysisGeneral MedicineMedical Science and ResearchHealth InformaticsClinical Research EthicsClinical ResearchPharmaceuticalsDiagnostic TestsDrug DevelopmentHealthcare EthicsLife SciencesPatient-centered CarePharmacologyPsychiatryMolecular Biology

Программа курса

6 модулей · 77 учебных материалов

01UNIT 1: INTRODUCTION TO PERSONALIZED MEDICINE18 материалов

WELCOME

A welcome message from Dr. RodenВидеоAbout this courseЧтение

Module 1: Fundamental Definitions and Concepts

Introduction to Personalized MedicineВидеоGenetics Definitions, Part IВидео

Учитесь у экспертов

Dan Roden, M.D.

Professor of Medicine and Pharmacology

Case Studies in Personalized Medicine
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Обучение откроется на Coursera
в новой вкладке

Обучение на Coursera

≈ 19.2 ч

6 модулей

Язык: Английский

Субтитры: Арабский, Французский, Бенгальский, Украинский, Китайский (Китай), Греческий, Итальянский, Бразильский португальский, Нидерландский, Корейский, Немецкий, Пушту, Урду, Русский, Тайский, Индонезийский, Шведский, Турецкий, Азербайджанский, Испанский, Дари, Хинди, Японский, Казахский, Венгерский, Польский

Часть программы вашего университета
Genetics Definitions, Part II & Types of Genetic VariantsВидео
Data Analysis, Part I: What is a Good Study?Видео
Data Analysis, Part II: What is a Good Test?Видео

Module 2: Drug Actions and Reactions

Introduction to Drug Therapy and General Mechanisms Underlying Variability in Drug ResponsesВидеоVariability in Drug TherapyВидеоDrug Metabolism & TransportВидеоGenetic Variability in Drug-Handling MoleculesВидео**Inside VUMC: The Promise of Personalized MedicineВидео

Unit 1 Discussions & Quiz

What kinds of data are helpful?ОбсуждениеWhat is a good study?ОбсуждениеWhat is a good test?ОбсуждениеWhy might an individual who has a non-sense variant not have a phenotype?ОбсуждениеWhat are causes of variability in drug action?ОбсуждениеIntroduction to Personalized MedicineЗадание
02UNIT 2: STUDYING GENETIC VARIATION12 материалов

Module 3: Finding Genetic Variants in Families and Populations

Family History and Inheritance PatternsВидеоAncestry: Genetic Variation Across Generations and GeographyВидеоFinding Disease-Associated Genes: LinkageВидео**Inside VUMC: From Phenotype to Genotype and Back: Studying Heart Disease in FamiliesВидео

Module 4: Contemporary Techniques and Technologies Used to Study Genetic Variation

Genome-Wide AssociationВидеоSequencingВидео**Inside VUMC: History of Sequencing TechnologiesВидео

Unit 2 Discussions & Quiz

What are causes of incomplete penetrance?ОбсуждениеHow big should your GWAS sample size be?ОбсуждениеHow big would the odds ratio need to be?ОбсуждениеCan sequencing inform understanding of common diseases?ОбсуждениеStudying Genetic VariationЗадание
03UNIT 3: CASE STUDIES IN PERSONALIZED MEDICINE, PART 118 материалов

Module 5: From Rare Disease to Common Medication - Familial Hypercholesterolemia

From rare to common disease: familial hypercholesterolemiaВидеоUsing Genomics to Find New Drug Targets: Familial HypercholesterolemiaВидеоMuscle Pains During Statin Therapy (Myopathy)Видео

Module 6: High Risk Pharmacogenetics

HLA-Mediated Immune Reactions (Skin Rash)ВидеоLong QT Syndromes, Part 1ВидеоLong QT Syndromes, Part 2Видео**Inside VUMC: Studying Cardiac Arrhythmias in CellsВидеоA Second Heart Attack a Month After a FirstВидеоHeadache During Venlafaxine (Antidepressant)ВидеоRespiratory Arrest After TonsillectomyВидеоA Bleeding Complication 5 Days After Starting WarfarinВидео**Inside VUMC: GenotypingВидеоDrug Metabolism and Variable Drug Responses – Four More ExamplesВидео

Unit 3 Discussions & Quiz

PCSK9 mutations and familial hypercholesterolemiaОбсуждениеSimvastatin-related myopathyОбсуждениеWhich drug-gene interactions warrant testing?ОбсуждениеShould RCTs be done on every pharmacogenomic association before clinical implementation?ОбсуждениеCase Studies, Part IЗадание
04UNIT 4: CASE STUDIES IN PERSONALIZED MEDICINE, PART 214 материалов

Module 7: From Mechanisms to Treatment

Cystic FibrosisВидеоMarfan SyndromeВидеоA Case of Idiopathic Heart FailureВидеоPersonalizing Care in Neuropsychiatric DiseaseВидеоPersonalizing Care in DiabetesВидеоGenomics to Subtype CancerВидеоA Family Member With Breast CancerВидеоA Family Member With Colon CancerВидео**Inside VUMC: Organizing Infrastructure to Support Genetic Testing DecisionsВидео

Unit 4 Discussions & Quiz

How much should a drug cost?ОбсуждениеWhat data are needed in decisions about starting lithium therapy?ОбсуждениеWould you order a CYP2D6 genotype before starting venlafaxine?ОбсуждениеWhen to test for BRCA1 mutations?ОбсуждениеCase Studies, Part IIЗадание
05UNIT 5: PERSONALIZED MEDICINE IN A SYSTEM OF CARE13 материалов

Module 8: Where We Are & Where We’re Going

Where We Are NowВидеоWhere We Are GoingВидео**Inside VUMC: Using iPSCs: Drug Discovery and Drug EfficacyВидео**Inside VUMC: Generating iPSCsВидео

Module 9: The Role of the Electronic Medical Record

Electronic Medical Records & The Learning Healthcare System (Discovery)ВидеоUsing Electronic Records to Personalize Care (Delivery)Видео**Inside VUMC: Using the EMR to Ascertain Patients for Genetic StudiesВидео**Inside VUMC: Biobanking & DNA Extraction at BioVUВидео**Inside VUMC: Personalized Medicine is a Team SportВидео

Unit 5 Discussions & Quiz

What limits our use of genomic sequencing data in practice?ОбсуждениеWhat are possible drawbacks to widespread use of EMRs?ОбсуждениеWhat are the barriers to widespread implementation of genomic medicine?ОбсуждениеPersonalized Medicine in a System of CareЗадание
06FINAL REFLECTION ACTIVITY2 материалов

CHOOSE ONLY ONE:

For Healthcare ProfessionalsВзаимная проверкаFor a General Audience (not Healthcare Professionals)Взаимная проверка