Pharmacokinetics

О курсе

This course begins with a review of routes of administration, ADME (absorption, distribution, metabolism, & excretion), and the use of in vivo drug concentration-time data to determine key pharmacokinetic parameters, like volume of distribution, half-life and clearance.  The course then emphasizes in vitro assays that allow rapid prediction of ADME and PK properties for evaluation of new compounds.  The later stages of the course focus on how drug discovery teams study this PK/PD relationship, as well as dose size and frequency predictions which ultimately assist in selection of a compound for advancement into the clinic.   This course is suitable for life scientists, clinicians, and individuals from fields that support drug discovery (e.g., patents, finance, licensing, etc.) interested in learning more about the pharmaceutical/biotechnology sector. Advanced undergraduate coursework or practical familiarity/working knowledge in biological sciences and organic chemistry is recommended.

Навыки, которые вы освоите

Учитесь у экспертов

Erland Stevens, PhD

James G. Martin Professor of Chemistry, Davidson College

W. Ross Tracey, PhD

Associate Director, Biomedical Research Learning, Novartis

Douglas S. Auld, PhD

Associate Director, Discovery Sciences, Biomedical Research, Novartis

Alan P. Brown, PhD, DABT

Director, Preclinical Safety, Biomedical Research, Novartis

Sujal Deshmukh, PhD

Director, Pharmacokinetic Sciences, Biomedical Research, Novartis

Stephanie Dodd, MSc.

Associate Director, Chemical & Pharmaceutical Profiling, Development, Novartis

Sabine Guth, PhD

Director, Diseases Of Aging and Regenerative Medicine, Biomedical Research, Novartis

Thomas M. Smith, PhD

Associate Director, Early Strategic Partnerships Biomedical Research, Novartis