Pharmacokinetics: Drug Dosing in Renal Disease

О курсе

This course provides a comprehensive foundation in clinical pharmacokinetics as applied to patients with renal impairment. Learners begin with kidney anatomy and physiology, connecting glomerular filtration, tubular secretion, and tubular reabsorption to the concepts of renal clearance and drug elimination. The course then explores acute kidney injury versus chronic kidney disease, including CKD staging, common causes and mechanisms of chronic renal failure, and how progressive loss of renal function alters drug handling over time. Building on this foundation, learners practice estimating renal function using serum creatinine, creatinine clearance calculations, and interpretation of eGFR. You will calculate renal clearance using excretion‑rate and urinary‑recovery methods and relate these to total body clearance. The course then focuses on practical dosing: adjusting doses and dosing intervals based on creatinine clearance/eGFR and drug-specific guidelines, with special emphasis on drugs with narrow therapeutic indices and predominantly renal elimination. You will apply therapeutic drug monitoring concepts in renal dysfunction, recognize and prevent drug-induced nephrotoxicity, and manage nephrotoxic reactions when they occur. Finally, the course examines how dialysis affects pharmacokinetics, including dialysability determinants and differences among modalities, and guides you in selecting and timing drug dosing for patients on hemodialysis or peritoneal dialysis, as well as designing comprehensive pharmacotherapeutic plans for chronic renal failure and its key complications.

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Hsiang-Yin Shawn Chen

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