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Precision Medicine · LearnSpace
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Precision Medicine

Курс от University of Geneva
Средний≈ 28.5 чАнглийский
О курсеНавыкиПрограммаПреподаватели

О курсе

This course will provide you with the key knowledge and tools to understand the fundamentals and practical implications of precision medicine, its opportunities and challenges. It will address precision-medicine era diagnostics, treatment selection, genetic counseling, public health interventions, and biomedical research. It will also deal with data science and ethical issues. From genomic analysis and genetic counseling to cancer biomarkers, from risk assessment of chronic diseases to the understanding of gene-environment interactions, from pharmacogenomics to multi-omics data integration, experts will walk you through the many aspects of precision medicine, from the bench to the bedside and to population health. Designed for students with a bachelor-level training in life sciences, this course will also be useful for professionals who are increasingly expected to deal with precision medicine, including primary care physicians and other first-line healthcare professionals, cancer and non-communicable diseases specialists, public health policy and decision makers, as well as biomedical researchers and drug developers. Experts from the multiple domains of genetics and genomics, oncology, pharmacology, data sciences, ethics, and biomedical research will provide you with a comprehensive, multi-faceted overview of precision medicine, richly illustrated with practical examples and clinical case studies, and peppered with formative evaluations. Whether you are interested or intrigued by topics such as “genethics”, the analysis of exome sequencing, precision diabetes management, hereditary cancers, the ongoing revolution of genetic technologies, genome-exposome interactions, the pharmacogenetics of opioids, data deidentification, blockchain-base patient-consent documentation, or proteomics and biomarkers, this course will explain the concepts, offer insights and present concrete examples, thus providing you with an overall understanding of the rapidly evolving field of precision medicine. - update - The contents of this course have been updated and important corrections have been implemented thanks to learners' feedback. Many thanks to them!

Навыки, которые вы освоите

Precision MedicineOncologyBioinformaticsPrimary CareDiagnostic TestsPharmacologyBiomedical TechnologyPharmacotherapyPharmaceuticalsData EthicsGeneral MedicineClinical ResearchBiotechnologyMolecular BiologyHealth PolicyClinical Research EthicsHealth InformaticsHealthcare EthicsPatient Education And CounselingMedical Science and Research

Программа курса

6 модулей · 154 учебных материалов

01Monogenic Diseases23 материалов

Welcome to the course

TrailerВидеоWelcome to the courseВидео📢 Important preliminary information: Evaluations and subtitlesЧтениеSyllabusЧтение

Учитесь у экспертов

Antoine Geissbuhler

Professor and Vice-rector, Head of Division

Idris Guessous

Professor, Head of Division

Caroline Samer

Professor, Head of Unit

Christelle Borel

Privat-Docent, Senior Research Associate

Petros Tsantoulis

Senior Clinical Associate

Precision Medicine
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Обучение на Coursera

≈ 28.5 ч

6 модулей

Язык: Английский

Субтитры: Арабский, Французский, Бенгальский, Украинский, Китайский (Китай), Греческий, Итальянский, Бразильский португальский, Нидерландский, Корейский, Немецкий, Пушту, Урду, Русский, Тайский, Индонезийский, Шведский, Турецкий, Азербайджанский, Испанский, Дари, Хинди, Японский, Казахский, Венгерский, Польский

Часть программы вашего университета
List of TeachersЧтение
Bibliographic ReferencesЧтение

Introduction to monogenic disorders

Introduction to the moduleВидео

Human genome variability and phenotype consequences

Human genome variabilty and phenotype consequences 1ВидеоHuman genome variability and phenotype consequences 2ВидеоHuman genome variability and phenotype consequencesЗадание

Case study

Medical consultation (part 1)ВидеоMedical consultation part 1ЗаданиеExome sequencing analysisВидеоWhat are the options? discussion between the physician and the biologistВидеоExome sequencing analysisЗаданиеMedical consultation (part 2)Видео

Monogenic disorders: challenges and perspectives

Rare genetic disorder and precision medicineВидеоRare genetic disorder and precision medicineЗадание

Genethics

Ethical, Legal and Social Implications (ELSI)ВидеоEthical, Legal and Social Implications (ELSI)Задание

Conclusion of Module 1

ConclusionВидео📢 Important preliminary information: Evaluations and subtitlesЧтениеMonogenic diseaseЗадание
02Complex Diseases17 материалов

Introduction

IntroductionВидео

Genetics of complex disorders

Genetics of complex disordersВидеоGenetics of complex disordersЗадание

Environmental determinant

Environmental determinantВидеоEnvironmental determinantsЗадание

Case study - part 1, current approaches

Diabetes management todayВидеоDiabetes management todayОбсуждениеDiabetes risk assessment part 1ВидеоThe key points - answers to the discussion by the expert (part 1)ВидеоHow to evaluate the disease risk (part 1)Задание

Case study - part 2, future approaches

Precision approaches in diabetesВидеоPrecision approches in diabetesОбсуждениеDiabetes risk assessment (part 2)ВидеоThe key points - answers to the discussion by the expert (part 2)ВидеоHow to evaluate the disease risk (part 2)Задание

Conclusion

ConclusionВидеоComplex diseaseЗадание
03Cancer36 материалов

Introduction

Somatic mutation theory of cancerВидеоSommatic mutation theory of cancerЗаданиеSynthetic lethality and oncogene addictionВидеоSynthetic lethality and oncogene addictionЗаданиеClinically-orientated analysisВидеоIntroduction to clinical ethicsВидеоIntroduction to clinical ethicsЗадание

Implementation of precision oncology

Objectives of precision oncologyВидеоObjectives of precision oncologyЗаданиеTumor classificationВидеоTumor classificationЗаданиеWhat is a biomarker?ВидеоWhat is a biomarker?ЗаданиеSomatic bioinformatics pipelines

Oncogenetics

Sporadic, familial and hereditary cancerВидеоSporadic, familial and hereditary cancerЗаданиеFamily history in oncologyВидеоFamily history in oncologyЗаданиеGenetic counselling in oncologyВидеоGenetic counselling in oncologyЗадание

Case studies

Case study 1 - part 1ВидеоCase Study 1 - part 1ЗаданиеCase study 1 - part 2ВидеоCase Study 1 - part 2ЗаданиеCase study 2 - part 1ВидеоCase Study 2 - part 1ЗаданиеCase study 2 - part 2

Conclusion

CancerЗаданиеFurther readingЧтение
04Health and Prevention21 материалов

Welcome to the module

Introduction to the moduleВидео

Introduction

The Revolution of Genetic TechnologiesВидеоMain Opportunities of GenomicsВидеоTesting the opportunities discussedЗаданиеGenomics and Complex Chronic DiseasesВидеоTesting the illustration discussedЗадание

Interaction

The Revolution of Environmental TechnologiesВидеоTesting the concept of behaviomeЗаданиеGenome-Exposome InteractionВидеоTyrell and all.ЧтениеTesting the understanding of the Tyrell and all. resultsЗаданиеBig DataВидео

Challenges of translating genomics into clinical care

Validity and Massive InformationВидеоRestitution, Unintended Findings and Actionable VariantsВидеоTesting challenges of translating genomics into clinical careЗадание

Key role of primary care physician in the era of precision medicine

Patients' Willingness to Discuss their Genomic InformationВидеоEvidence-Based Precision MedicineВидео

Conclusion

ConclusionВидеоNew Technologies and Personalized Health: Opportunities and ChallengesВидеоHealth and preventionЗадание
05Pharmacogenomics and Drug Development37 материалов

General principles in pharmacogenetics

Introduction to the moduleВидеоVariability in drug responseВидеоVariability in drug responseЗаданиеDrug metabolismВидеоDrug metabolismЗаданиеRole of Transporters in Drug DispositionВидеоRole of Transporters in Drug DispositionЗадание

Pharmacogenomics and cardiovascular medicine

Case - Pharmacogenomics of StatinsВидеоPharmacogenomics of statinsЗаданиеOther Cardiovascular Case StudiesВидеоOther cardiovascular diseasesЗадание

Pharmacogenomics and pain

Codeine Intoxication Associated with Ultrarapid CYP2D6 MetabolismЧтениеPharmacogenomics of opioidsВидеоPharmacogenomics of opioidsЗаданиеTools for clinicians and patientsВидеоTable of Pharmacogenetic AssociationsЧтениеTools of clinicians and patientsЗадание

Lab tools to support personalized therapy and pharmacogenomics

Current Methods to Identify Pharmacogenomics VariantsВидеоCurrent Methods to Identify Pharmacogenomics VariantsЗаданиеPhenotyping in the labВидеоCase study: antiaggregant and HIVЧтениеCase Study: the example of oxycodoneЧтениеPhenotyping in the labЗадание

Pharmacogenomics and drug development

Drug development 1ВидеоDrug development 1ЗаданиеDrug development 2ВидеоDrug development 2ЗаданиеPharmacovigilanceВидеоPharmacovigilanceЗаданиеPharmacoeconomics of pharmacogenomics

Blockchain and data deidentification

Citizen Centered ConsentВидеоCitizen Centered ConsentЗаданиеData deidentificationВидеоData DeidentificationЗадание

Conclusion

Conclusion and Future PerspectivesВидеоPharmacogenomics and Drug DevelopmentЗадание
06Research20 материалов

Introduction

Introduction to the moduleВидео

Precision medicine research project

First Steps of a Research ProjectВидеоFirst steps of a research projectЗаданиеSample Collection, Biobanking and Data Generation/RecordingВидеоSample collection, biobanking and data generation/recordingЗаданиеData Quality Control and Data AnalysisВидеоData dissemination, databases and publicationВидеоOn Data videos above (2)Задание

Example of a precision medicine project (part 1)

Estimating the causal tissues for complex traits and diseasesЧтениеQuestions on published articleЗаданиеExplanations by the expertВидеоAbstract section of the articleЧтениеQuestions on abstractЗадание

Example of a precision medicine research project (part 2)

Explanation by the expert: patient stratification in traumatic brain injuryВидеоPatient stratification in traumatic brain injuryЗаданиеExplanations by the expert: Steroid Signatures in ToxicologyВидеоSteroid signatures in toxicologyЗадание

Conclusion

Conclusion of the moduleВидеоResearchЗадание

Thank you for joining us

Conclusion of the course in Precision MedicineВидео
Видео
Somatic bioinformatics pipelineЗадание
Molecular tumor boardВидео
Molecular tumor boardЗадание
Ethical and societal implicationsВидео
Ethical and societal implicationsЗадание
Main hereditary cancer syndromesВидео
Main hereditary cancer syndromesЗадание
Видео
Big DataЗадание
Видео
Pharmacoeconomics and pharmacogenomicsЗадание