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Targets, Assays & Screening · LearnSpace
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Targets, Assays & Screening

Курс от Novartis
Средний≈ 8.7 чАнглийский
О курсеНавыкиПрограммаПреподаватели

О курсе

This course focuses on the early stages of drug discovery and the identification of promising compounds with which to begin the hunt for a novel drug.  Different types of assays and methods are reviewed that are used to screen libraries of molecules in the preliminary search for compounds with activity.  Methods are discussed for validating that active molecules are indeed engaging a target associated with a predicted therapeutic benefit. Target audience: This course is suitable for life scientists, clinicians, and individuals from fields that support drug discovery (e.g., patents, finance, licensing, etc.) interested in learning more about the pharmaceutical/biotechnology sector. Advanced undergraduate coursework or practical familiarity/working knowledge in biological sciences and organic chemistry is recommended.

Навыки, которые вы освоите

Biochemical AssaysDrug DevelopmentPharmaceuticalsLaboratory ResearchVerification And ValidationMolecular BiologyChemistryPre-Clinical DevelopmentPharmacologyBiochemistry

Программа курса

3 модулей · 34 учебных материалов

01Targets, Assays & Screening, part 110 материалов

Welcome

Course WelcomeВидео

Interview with Scott Busby, Discovery Sciences

Interview with Scott Busby, Discovery SciencesВидео

Early Discovery Definitions

Early Discovery DefinitionsВидеоKnowledge CheckЗадание

Target-Based Drug Discovery

Учитесь у экспертов

Erland Stevens, PhD

James G. Martin Professor of Chemistry, Davidson College

W. Ross Tracey, PhD

Associate Director, Biomedical Research Learning, Novartis

Douglas S. Auld, PhD

Associate Director, Discovery Sciences, Biomedical Research, Novartis

Alan P. Brown, PhD, DABT

Director, Preclinical Safety, Biomedical Research, Novartis

Sujal Deshmukh, PhD

Director, Pharmacokinetic Sciences, Biomedical Research, Novartis

Stephanie Dodd, MSc.

Associate Director, Chemical & Pharmaceutical Profiling, Development, Novartis

Sabine Guth, PhD

Director, Diseases Of Aging and Regenerative Medicine, Biomedical Research, Novartis

Thomas M. Smith, PhD

Associate Director, Early Strategic Partnerships Biomedical Research, Novartis

Targets, Assays & Screening
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Обучение на Coursera

≈ 8.7 ч

3 модулей

Язык: Английский

Часть программы вашего университета
Target-Based Drug DiscoveryВидео
The complement system as an example of target selectionЧтение

Phenotypic Drug Discovery

Phenotypic Drug DiscoveryВидеоRecent Advances in Phenotypic Drug DiscoveryЧтениеKnowledge CheckЗаданиеAssessmentЗадание
02Targets, Assays & Screening, part 214 материалов

Factors in Assay Design

Factors in Assay DesignВидеоIC50 and KiЧтениеKnowledge CheckЗадание

Molecular Space

Molecular SpaceВидеоKnowledge CheckЗадание

Compound Libraries

Compound LibrariesВидеоKnowledge CheckЗадание

High-Throughput Screening and the Primary Assay

High-Throughput Screening and the Primary AssayВидеоEvolution of commercially available compounds for HTSЧтениеKnowledge CheckЗадание

Orthogonal Assays, Counterscreens, and PAINS

Orthogonal Assays, Counterscreens, and PAINSВидеоAssay Interference by AggregationЧтениеKnowledge CheckЗаданиеAssessmentЗадание
03Targets, Assays & Screening, part 3 10 материалов

Fragment-Based Drug Discovery

Fragment-Based Drug DiscoveryВидеоImproving potency of fragmentsЧтение

In Silico Screening

In Silico ScreeningВидеоKnowledge CheckЗадание

Hit Validation

Hit ValidationВидеоHit Validation MethodsЧтение

Future Directions in Screening

Future Directions for ScreeningВидеоKnowledge CheckЗаданиеAssessmentЗадание

Farewell

Farewell Видео