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Toxicology 21: Scientific Applications · LearnSpace
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Toxicology 21: Scientific Applications

Курс от Johns Hopkins University
Средний≈ 167.4 чАнглийский
О курсеНавыкиПрограммаПреподаватели

О курсе

This course familiarizes students with the novel concepts being used to revamp regulatory toxicology in response to a breakthrough National Research Council Report “Toxicity Testing in the 21st Century: A Vision and a Strategy.” We present the latest developments in the field of toxicology—the shift from animal testing toward human relevant, high content, high-throughput integrative testing strategies. Active programs from EPA, NIH, and the global scientific community illustrate the dynamics of safety sciences.

Навыки, которые вы освоите

Molecular BiologyBiologyAnalytical TestingEndocrinologyEnvironmental RegulationsHazard AnalysisBioinformaticsBiochemistryLaboratory TestingBiochemical AssaysCell CulturesData MiningEnvironmental ScienceMolecular, Cellular, and MicrobiologyChemistryPre-Clinical DevelopmentLaboratory ResearchPharmacology

Программа курса

7 модулей · 108 учебных материалов

01Module 115 материалов

Welcome to the Course

Welcome to Module 1ВидеоCourse IntroductionВидео

Drivers for Change

IntroductionВидеоCenter for Alternatives to Animal TestingВидеоToxicology of the Fifteenth to Twentieth Centuries

Учитесь у экспертов

Lena Smirnova

Research Associate

Thomas Hartung

Professor

Toxicology 21: Scientific Applications
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≈ 167.4 ч

7 модулей

Язык: Английский

Субтитры: Арабский, Французский, Украинский, Китайский (Китай), Греческий, Итальянский, Бразильский португальский, Нидерландский, Корейский, Немецкий, Русский, Тайский, Индонезийский, Шведский, Турецкий, Испанский, Хинди, Японский, Казахский, Польский

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Видео
Toxicology for the Twenty-First CenturyВидео
useful linksЧтение
supporting reading materialЧтение

The National Research Council (NRC) Report - Toxicity Testing in the 21st Century: A Vision and a Strategy

Historical PerspectiveВидеоThe First Report: Toxicity Testing for Assessment of Environmental AgentsВидеоThe Second Report: Toxicity Testing in the 21st Century: A Vision and A Strategy Vision and Its ComponentsВидеоThe Second Report: Toxicity Testing in the 21st Century: A vision and A Strategy ImplementationВидеоSupporting reading materialЧтение

Check your knowledge

Module 1 QuizЗаданиеDrivers of changeОбсуждение
02Module 218 материалов

US EPA Endocrine Disruptor Screening Program (EDSP)

Welcome to Module 2ВидеоAdverse Outcome Pathways (AOPs)ВидеоExposure-Based Chemical PrioritizationВидеоER Bioactivity ModelВидеоUS EPA Endocrine Disruptor Screening Program (EDSP)ВидеоSupporting Reading MaterialЧтениеUseful linksЧтение

Modeling of Hazard and Organ Manifestation

Modeling of Hazard and Organ ManifestationВидеоBuilding a Signature for Vascular DisruptionВидеоTesting the Vascular Disruption SignatureВидеоVirtual Tissue Model: Vascular DevelopmentВидеоFunctional Vascular Development AssaysВидеоSupporting Reading MaterialЧтение

Check your knowledge

Module 2 QuizЗаданиеTox21 vs. ToxCastОбсуждениеAOPОбсуждение

Assignment 1: CompTox to prioritize chemicals

Chemical report and endocrine disrpution potency predictionВзаимная проверка
03Module 314 материалов

The Human Toxome Project

Welcome to Module 3ВидеоMechanistic Toxicology and Pathway Mapping at the Basics of 21st Century ToxicologyВидеоThe Concept of the Human Toxome ProjectВидеоConcept and Tool DevlopmentВидеоProgressВидеоConclusions and ProspectivesВидеоSupporting reading materialsЧтение

Pathways of Toxicity from Omics Data

Introduction: What Is a Pathway of Toxicity, and Why Do We Need Them?ВидеоOmics Technologies and High-Throughput DataВидеоInterpreting Omics DataВидеоUsing Network Approaches to Understand Toxicity MechanismsВидеоSupporting reading materialЧтение

Check your knowledge

Module 3 QuizЗаданиеChallenges in implementing omics technologies for high throughput assaysОбсуждение
04Module 424 материалов

The Adverse Outcome Pathway Framework: The Foundation for Predictive Toxicology

The Need, and Opportunity, for a New Approach to Toxicology, Including Predictive ToolsВидеоThe Concept of Toxicological (Biological) Pathways, e.g., “Adverse Outcome Pathways,” Is the Basis of Predictive ToxicologyВидеоIntroduction to the OECD AOP FrameworkВидеоBuilding, Evaluating, and Using AOPs in Safety DecisionsВидеоOnline Tools Available to Everyone, Including an Online AOP CourseВидео

Read-Across

Welcome to Module 4ВидеоIntroduction to Read-AcrossВидеоGood Read-Across PracticeВидеоSupporting Read-Across with Biological DataВидеоCreating a Database of ToxicityВидеоCreating an Automated Tool for Read-AcrossВидеоSupporting reading materialЧтение

Microphysiological Systems (Organ-on-Chip, Organoids, Organotypic Cultures) in Toxicology: Next Generation of Cell Cultures

Cell Sources for In Vitro ModelsВидеоMonolayer CulturesВидеоAdvanced Cell Cultures: Microphysiological Systems (MPS)Видео3D CulturesВидеоMicrofluidicsВидеоOrgan-on-Chip, Body-on-ChipВидео

Check your knowledge

Module 4 QuizЗаданиеRead-acrossОбсуждение

Mid-term exam

Mid-term examЗадание
05Module 59 материалов

Micro-RNA and epigenetics

Welcome to Module 5ВидеоMicroRNA and EpigeneticsВидеоEpigenetics and EnvironmentВидеоMicroRNA: Biogenesis and FunctionsВидеоRole of MicroRNA in DevelopmentВидеоMicroRNA in ToxicologyВидеоSupporting reading materialЧтение

Check your knowledge

Module 5 QuizЗаданиеMicroRNAs potential to be biomarkers for diseases and toxicityОбсуждение
06Module 613 материалов

Biokinetic Modeling of Toxicokinetics

Welcome to ModuleВидеоPhysiologically Based Biokinetic ModelingВидеоApplication of QIVIVE to in Vitro TestingВидеоChallenges for Conducting QIVIVEВидеоQuantitative in Vitro to in Vivo ExtrapolationВидеоSupporting reading materialЧтение

Biometry and Data-mining

Definition of Biometry/Biostatistics and Revisiting Some Statistical BasicsВидеоTypes of Tox21 Data and Data Mining of External Data SourcesВидеоBioinformatics Tools for the Interpretation of Tox21 DataВидеоSupporting reading materialЧтениеUseful linksЧтение

Check your knowledge

Module 6 QuizЗадание

Peer Assessment 2 (to be moved)

Peer Assessment 2: Summarizing Your Knowledge on Tools and Applications in Toxicology in the 21st CenturyВзаимная проверка
07Module 715 материалов

Integrated Testing Strategies

Welcome to Module 7ВидеоWhy Integrated Testing Strategies?ВидеоWhat is an Integrated Testing Strategy?ВидеоHow to Compose Integrated Testing StrategiesВидеоStrategies for Integrated Testing StrategiesВидеоQuality Assurance of integrated Testing StrategiesВидеоSupporting reading materialЧтение

Beyond Chemicals

Legal BackgroundВидеоEconomic BackgroundВидеоTox-21c for Drug SafetyВидеоGreen Toxicology as Non-regulatory Tox-21c ApproachesВидеоConclusions and ProspectsВидеоSupporting reading materialЧтение

Check your knowledge

Module 7 QuizЗадание

Final Exam

Final ExamЗадание
Useful linksЧтение
Good Cell Culture PracticeВидео
Supporting reading materialЧтение
Useful linksЧтение