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Translational Medicine 1: Gene Editing & Molecular Imaging · LearnSpace
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Translational Medicine 1: Gene Editing & Molecular Imaging

Курс от Taipei Medical University
Средний≈ 11.2 чАнглийский
О курсеНавыкиПрограммаПреподаватели

О курсе

This course gives you easy access to the invaluable techniques used by leading biomedical experts to bridge the gap between laboratory discovery and real-world clinical practice. By completing this course, you will learn how to explain gene therapy principles using modified viral vectors, and analyze structural glycosylation mechanisms to identify crucial clinical biomarkers. Furthermore, you will outline the essential stages of preclinical development—including animal models, toxicology, and regulatory steps—and evaluate how molecular imaging modalities visualize diseases at the cellular level. Learners will benefit from a comprehensive, behind-the-scenes look at the medical research pipeline. You will understand exactly how theoretical science and foundational biochemistry transform into safe, human-ready clinical trials. What makes this course unique is its seamless integration of diverse, cutting-edge disciplines. Rather than viewing biology in isolation, we combine structural biology, in vivo imaging, and modern therapeutics. Whether your interest lies in oncology, immunology, or genetic disorders, this course equips you with the fundamental expertise needed to navigate and innovate within the rapidly evolving fields of biotechnology and translational medicine.

Навыки, которые вы освоите

Medical ImagingPre-Clinical DevelopmentBiotechnologyBiochemistryClinical TrialsMolecular BiologyOncologyRadiologyMedical Science and ResearchExperimentationClinical PracticesClinical ResearchClinical InformaticsClinical Laboratory ScienceBiomedical EngineeringPharmacology

Программа курса

4 модулей · 49 учебных материалов

01Viral Vector in Gene Therapy13 материалов

Viral Vector in Gene Therapy

Course OverviewЧтениеModule 1 Viral Vector in Gene Therapy Slides and IntroductionЧтение1.1 Principles of Gene TherapyВидео1.2 Principles of Viral Vectors and Retrovirus EngineeringВидео

Учитесь у экспертов

Yi-Fan Chen

Преподаватель курса

Translational Medicine 1: Gene Editing & Molecular Imaging
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Обучение на Coursera

≈ 11.2 ч

4 модулей

Язык: Английский

Часть программы вашего университета
1.3 Retroviral Gene Therapy HistoryВидео
1.4 Lentiviruses and CAR-T TherapyВидео
1.5 Introduction to AAV SystemsВидео
1.6 Comparison of Viral Vectors in Clinical TrialsВидео
1.7 Future of Viral Vector EngineeringВидео

Weekly Assessment: Viral Vector in Gene Therapy

Supplemental Reading: Biosafety Challenges and Vector Engineering in Gene TherapyЧтениеModule Supplemental Reading: The Evolution and Commercialization of Gene TherapyЧтениеModule 1 Reflection: Balancing Efficacy and Safety in Viral Vector Gene TherapyЗаданиеCritical Reflection: Vector Selection and Clinical Success in Gene TherapyЗадание
02Introduction to Glycoscience and Glycomics14 материалов

Introduction to Glycoscience and Glycomics

Welcome to this module on glycoscienceЧтение2.1 Fundamentals of Glycoscience and GlycomicsВидео2.2 Functional Roles of Glycosylation in CellsВидео2.3 Synthesis and Types of N-Linked GlycansВидео2.4 N-Glycan Branching and Extension ProcessВидео2.5 O-Glycosylation and Core StructuresВидео2.6 Types and Functions of Galectins and LectinsВидео2.7 Glycosylation in Biologics and PharmaceuticalsВидео2.8 The Role of Glycosylation in Influenza VirusВидео

Discussion and Supplement Reading

Navigating the Viral Glycan Shield in Therapeutic DesignDIALOGUESupplemental Reading: Principles of Glycosylation and the Frontier of GlycomicsЧтениеSupplemental Review Paper: Glycosylation: mechanisms, biological functions and clinical implicationsЧтение

Weekly Assessment: Glycoscience and Glycomics

Viral Vector in Gene Therapy Slides and IntroductionЗаданиеViral Vector in Gene Therapy Slides and IntroductionЗадание
03Foundations of Preclinical Development and Animal Models10 материалов

Foundations of Preclinical Development and Animal Models

Welcome to this moduleЧтение3.1 Principles of Preclinical Drug Development and Animal Disease ModelingВидео3.2 Principles of Cloning and Embryonic Stem Cell ManipulationВидео3.3 Site-Specific Recombination and Immunodeficient Mouse ModelsВидео3.4 Humanized Mouse Models and Preclinical Toxicology FrameworksВидео3.5 Translational Preclinical Models in Drug DevelopmentВидео

Practice and Assessment

The Translational Dilemma: Navigating Animal Model Selection in Pre-Clinical TrialsDIALOGUEWhen Mice Lie: The Promise and Limits of Animal Models in Drug DevelopmentЧтениеReflect on What You Have LearntЗаданиеAssessment Time Задание
04An Introduction to Molecular Imaging for Translational Research12 материалов

An Introduction to Molecular Imaging for Translational Research

An Introduction to Molecular Imaging for Translational ResearchЧтение4.1 Fundamentals of Molecular Imaging in Translational ResearchВидео4.2 Fluorescence Optical Imaging in Tumor and Vascular Development ModelsВидео4.3 Bioluminescence Optical Imaging in Orthotopic Tumor ModelsВидео4.4 Translational Molecular Imaging in Glioblastoma Immunotherapy ModelsВидео4.5 Clinical Translation and Multi-Modality Molecular ImagingВидео

Discussion and Assessment

Molecular Imaging Biomarkers for Early Cancer Detection: A Systematic Review of Emerging Technologies and Clinical ApplicationsЧтениеThe Imaging Modality Dilemma in Clinical TrialsDIALOGUEMolecular Imaging Modalities and Their ApplicationsЗаданиеMolecular Imaging in Translational ResearchЗадание

Summative Assesment

Final Course AssessmentЗаданиеCourse feedback and further learningОбсуждение